Non-convulsive seizure related to Cremophor EL™-free, polymeric micelle formulation of paclitaxel: a case report
نویسندگان
چکیده
منابع مشابه
Phase I and pharmacokinetic study of Genexol-PM, a cremophor-free, polymeric micelle-formulated paclitaxel, in patients with advanced malignancies.
PURPOSE The rationale for developing an alternative paclitaxel formulation concerns Cremophor EL-related side effects, and a novel paclitaxel delivery system might augment its therapeutic efficacy. Genexol-PM is a polymeric micelle formulated paclitaxel free of Cremophor EL. A phase I study was performed to determine the maximum tolerated dosage, dose-limiting toxicities, and the pharmacokineti...
متن کاملDevelopment and characterization of a novel Cremophor EL free liposome-based paclitaxel (LEP-ETU) formulation.
Taxol is a marketed product for the treatment of ovarian, breast, non-small cell lung cancer and AIDS-related Kaposi's Sarcoma. It is thus far one of the most effective anticancer drugs available on the market. However, paclitaxel is only sparingly soluble in water and therefore, intravenous administration depends on the use of the non-ionic surfactant Cremophor EL (polyethoxylated castor oil) ...
متن کاملA Case of Ischemic Colitis Associated with Paclitaxel Loaded Polymeric Micelle (Genexol-PM
DOI: 10.4046/trd.2010.69.2.115 ISSN: 1738-3536(Print)/2005-6184(Online) Tuberc Respir Dis 2010;69:115-118 CopyrightC2010. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved. A Case of Ischemic Colitis Associated with Paclitaxel Loaded Polymeric Micelle (Genexol-PM R ) Chemotherapy Choel-Kyu Park, M.D., Hyun-Wook Kang, M.D., Tae-Ok Kim, M.D., Ho-Seok Ki, M.D., Eun-Y...
متن کاملAn Open-Label, Randomized, Parallel, Phase II Trial to Evaluate the Efficacy and Safety of a Cremophor-Free Polymeric Micelle Formulation of Paclitaxel as First-Line Treatment for Ovarian Cancer: A Korean Gynecologic Oncology Group Study (KGOG-3021)
PURPOSE Genexol-PM is a biodegradable cremophor EL-free polymeric micelle formulation of paclitaxel. Here,we compared efficacy and safety of Genexol-PM plus carboplatin versus Genexol plus carboplatin for ovarian cancer treatment. MATERIALS AND METHODS In this multicenter, randomized, phase II study, patients with International Federation of Gynecology and Obstetrics IC-IV epithelial ovarian ...
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pyridoxine dependent seizure have been recornized as a rare and important cause of intractable seizure in neonates and infants.prompt diagnosis and treatment can stop and prevent these seizure and consequential developmental disabilities.furthermore it can eliminate the unnecessary administration of anticonvulsant medications and thier side effects.the paitient was 7 months old infant who was r...
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ژورنال
عنوان ژورنال: Obstetrics & Gynecology Science
سال: 2018
ISSN: 2287-8572,2287-8580
DOI: 10.5468/ogs.2018.61.3.421